Investigation on an application of silver substrates for sensitive surface plasmon resonance imaging detection.

نویسندگان

  • Seung Ho Choi
  • Kyung Min Byun
چکیده

A surface plasmon resonance (SPR) imaging biosensor based on silver substrates was investigated to demonstrate that silver could be used as a substrate material for sensitive detection of biomolecular interactions, despite its poor chemical stability. The calculation results showed that oxidation of silver film may lead to a decrease in the sensitivity due to a variation in SPR characteristics such as a broader curve width and shallower minimum reflectance at resonance. The effect of a change in the refractive index of target analytes on the sensitivity was also explored. In particular, it is noteworthy that Ag/Au bimetallic substrates with a thin gold protection layer to prevent oxidation of a silver film can provide a significant amplification of SPR imaging signals in comparison with conventional gold substrates.

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عنوان ژورنال:
  • Journal of the Optical Society of America. A, Optics, image science, and vision

دوره 27 10  شماره 

صفحات  -

تاریخ انتشار 2010